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Tablet-Based Treatment for Diabetes
in The Biotech Weblog, on September 1, 2009
© Sarah G... Scientists have developed what could be the first tablet-based treatment for children and adults with Type 1 diabetes . Early animal trials indicate that the anti-Ras FTS compound is effective in restoring insulin production in animal models ― which could spell an end to the d...
Anti-Inflammatory Constituents of Ginseng Identified
in The Biotech Weblog, on May 16, 2009
© centralasian Scientists have identified immunologically active components in ginseng, an herb used in traditional Chinese and other Asian medicine.
Allan Lau led a team of researchers from the University of Hong Kong who identified seven ginseng constituents, ginsenosides , which showed imm...
Saliva Test: Non-invasive Method To Detect Diabetes
in Daily Diabetic, on April 28, 2009
...omarkers that may indicate diabetes, doctors examined the saliva of 40 different patients. Through salivary analysis, they managed to devise a new "non-invasive" method for detecting diabete...
Prognostic Test for Frontotemporal Dementia
in The Biotech Weblog, on March 10, 2009
Photo courtesy of iStockphoto , Image# 6952418 A blood test has been developed to predict the risks of frontal lobe dementia (Frontotemporal Dementia, FTD), a form of dementia that occurs most frequently in patients younger than 65. The test is based on previous findings showing that a genetic d...
Brain Enzyme Regulates Appetite and Weight Gain
in The Biotech Weblog, on December 15, 2008
Scientists have determined that an enzyme in the brain called p70 S6 Kinase 1 or S6K may play a role in preventing weight gain and obesity. The researchers injected rats with special viruses that selectively raise or lower S6K activity and found that an increased S6K activity led to reductio...
Antioxidant in Green Tea May Delay Onset of Type 1 Diabetes
in Daily Diabetic, on October 27, 2008
...glands, causing dry mouth and eyes.
In the mouse, EGCG reduced the severity and delayed onset of salivary gland damage associated with Sjogren's syndrome, which has no known cure.
"EGCG ...
Biomarkers for Oral Cancer in Saliva
in The Biotech Weblog, on September 30, 2008
...t; Hu said. "We have demonstrated a new approach for cancer biomarker discovery using saliva proteomics ."
Researchers are currently working on a device to detect these biomarkers, a po...
Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)
in The Biotech Weblog, on September 11, 2008
6961047
Photo courtesy of iStockphoto, Rob Broek Researchers have identified proteins in urine samples which may be used as an indicator of the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.
The scientists analysed the proteins in urine samples taken from ...
Netzwerke der Zellen: Toponomik, neues Forschungsgebiet
in Das Gesundheits-Weblog, on 19.08.08
Da will ich doch gleich noch etwas Neues bieten. ein ganz neues Forschungsgebiet, und das ist nun wirklich Grundlagenforschung im engeren Sinne: oder haben Sie schon etwas von Toponomik gehört? Bisher steht es noch nicht einmal in wikipedia (vielleicht sollte ich einen Eintrag schreiben?* was für m...
At 35, I Got The Mumps!
in Straightfromthedoc, on June 10, 2008
...ts.
Mumps is a viral infection that primarily affects the parotid glands - one of three pairs of salivary glands, located below and in front of your ears. If you or your child contracts mumps, it ca...
RCSB Protein Data Bank Archives 50,000th Molecule Structure
in The Biotech Weblog, on April 10, 2008
The backbone structure of the infectious epsilon15 virus (PDB ID 3c5b, in photo) is the most recent addition to the Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, making it the 50,000th molecule structure released into the only worldwide repository for the three-...
Botox treat Hypersalivation in CHARGE Syndrome Patients
in The Biotech Weblog, on March 19, 2008
...cessfully control saliva production in CHARGE patients by injecting minute doses of Botox into the salivary glands .
Since this first attempt 5 years ago, Dr. Daniel has performed over 1000 botox ...
Two Protein Receptors Control Stomach Relaxation Identified
in The Biotech Weblog, on March 5, 2008
Scientists have identified 2 protein receptors in a guinea pig - P2Y1 and P2Y11 - that relax the gut and thus allow it to accommodate a bigger meal. these receptors are also present in humans and may serve as targets for developing drugs to aid in weight management and preventing obesity.
Dr Br...
Study Warns of Cancer Risk with Heavy Mobile Phone Use
in The Wireless Weblog, on February 19, 2008
...hone against one side of the head for several hours a day were 50% more likely to have developed a salivary gland tumor ," BBC News reports .
"The study also found an increased risk of c...
Osteocrin Protein Controls Bone Growth
in The Biotech Weblog, on December 23, 2007
Researchers have discovered protein that controls bone growth, and thus may be used as the basis for finding treatment for people with bone diseases affecting skeletal growth.
Osteocrin is a small protein produced by the body's bone-forming cells, or osteoblasts. In this study, mice...
Silk from Bees
in The Biotech Weblog, on November 29, 2007
Did you know that, like moths, spiders butterflies and silkworms, bees also produce silk?
Those are the latest findings reported recently in Molecular Biology and Evolution , which discusses the honeybee silk genes and the properties of the coil proteins from the cocoon and nest silk...
Novel D-Peptides More Potent Against HIV
in The Biotech Weblog, on October 11, 2007
Scientists at the University of Utah have developed new peptides that appear to be significantly more effective at blocking HIV's entry into cells than other drugs in their class.
"Our 'D-peptides' offer several potential therapeutic advantages over existing peptide entry inhi...
Progranulin Deletion or Mutation Leads to Toxic Proteins Build-up in Neurons
in The Biotech Weblog, on September 28, 2007
Researchers have discovered that a deletion of a gene for progranulin leads to the accumulation of toxic proteins in the brain which subsequently results to dementia.
In the Sept. 26 issue of the Journal of Neuroscience, the scientists demonstrate that absence of a gene known as progranulin lead...
Protein Biomarkers for Colorectal Cancer Identified
in The Biotech Weblog, on September 25, 2007
Using two-dimensional gel electrophoresis and mass spectrometry, 27 differentially expressed protein biomarkers for colorectal adenoma have been identified . The differential expression of two of these novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validat...
Identifying Biological Indicators of Exposure to Cigarette Smoke
in The Biotech Weblog, on September 18, 2007
The National Institutes of Health's new Genes, Environment, and Health Initiative (GEI) has awarded the Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania School of Medicine a grant of $2.3 million over the next four years to study biological indicators ...
Pepfactant® Switchable Peptide Surfactant
in The Biotech Weblog, on August 22, 2007
(Photo: The tube on the left shows the original emulsion, while the one on the right shows the rapid separation of the emulsion into oil and water after a newly developed "switchable" detergent is added. Credit: Annette dexter , University of Queensland)
Researchers have develop...
Anti-Diabetes Drug Candidate Liraglutide Improves Glucose Control and Lowers Body Weight
in The Biotech Weblog, on August 21, 2007
Two Phase III clinical trials involving more than 2000 patients have shown that Novo Nordisk's new anti-diabetes drug candidate liraglutide have a positive effect on blood glucose control, body weight and hypoglycaemia risks. Liraglutide is a once-daily human analogue of the naturally occurr...
ESF EURYI Awardee Tackles Topoisomerases to Control Cancer Growth
in The Biotech Weblog, on August 10, 2007
One of this year's ESF EURYI award winning projects explores a new line in anti-cancer therapy by blocking the molecular motors involved in copying genetic information during Cell division , which may be used to complement existing cancer therapies.
Dekker is focusing on an enzyme ...
Bone as Therapeutic Target for Type 2 Diabetes
in The Biotech Weblog, on August 10, 2007
A new study published in the August 10 issue of Cell indicates that the skeleton is not just for structural support, but also helps control sugar metabolism and weight and is thus a major determinant of the development of type 2 diabetes. Apparently, bone cells release a hormone called os...
REST Protein May Halt Cardiac Hypertrophy
in The Biotech Weblog, on June 6, 2007
Researchers have discovered that the progression of cardiac hypertrophy can be halted by increasing one of the body's naturally occurring proteins known as REST. Cardiac hypertrophy is a relatively common condition characterized by an abnormal thickening of the heart muscle.
Dr Ooi&...
Antibody Developed to Detect Mutant Enzyme Causing Amyotrophic Lateral Sclerosis
in The Biotech Weblog, on May 14, 2007
Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig 's disease, is a progressive and usually fatal neurological disorder that attacks the nerves and muscles. Researchers have now developed the first antibody that detects misfolded conformations of the enzyme superoxide-dimutase-1...
Proline Dehydrogenase Model Reveals Role in Apoptosis
in The Biotech Weblog, on May 13, 2007
In order to elucidate its function in apoptosis, researchers have created a model of proline dehydrogenase , an important cancer-preventing enzyme in the human body. Proline dehydrogenase enables the creation of superoxide, a highly reactive electron-rich oxygen species involved in the destruct...
Blood Test for the Early Diagnosis of Parkinson's Disease
in The Biotech Weblog, on April 28, 2007
A new blood test to diagnose Parkinson's disease (PD) before symptoms appear has been developed. The test measures the blood concentration of a brain-secreted protein called ' alpha-synuclein ', which is found to be low in PD patients.
"Currently there is no specific PD diag...
Saliva and Breast Cancer
in Well Woman Blog, on March 30, 2007
... that women visit their dentists more often than their physician may help with early detection. The salivary testing is also more beneficial than blood analysis as the saliva is a clear, colorless liq...
Biomarker Test for Bladder Cancer Recurrence and Survival
in The Biotech Weblog, on February 20, 2007
A new diagnostic test has been developed to better predict the recurrence and survival of bladder cancer patients. The test is based on the presence of molecular biomarkers Bcl-2 , caspase-3 , P53 and survivin -- proteins known to regulate apoptosis, or programmed cell death.
[snip] .....
Using Preteomic Profiling to Predict Premature Birth
in The Biotech Weblog, on February 12, 2007
...
Scientists have identified a proteomics-based method to predict the risks of pre-term childbirth due to amniotic fluid inflammation. A profile based on the presence of human neutrophil defensin 1,...
Protein Biomarkers Predict Bladder Cancer Recurrence and Survival
in The Biotech Weblog, on February 6, 2007
Based on the analysis of archival tissue from 226 patients who underwent surgery for bladder cancer, scientists were able to identify four protein biomarkers that could predict the recurrence of bladder cancer . The findings, which researchers say could one day alter the postoperative treatment...
Improving Crop Plants Through Genomics
in The Biotech Weblog, on January 30, 2007
...tural Research magazine . PSNL scientists are applying genomics and related sciences such as proteomics and computational biology to improve the nutritional value of leading crops, as well as b...
BH3 Profiling Determines Sensitivity to Experimental Cancer Drug
in The Biotech Weblog, on January 23, 2007
Researchers have developed a test called "BH3 profiling" to determine the levels of the Bcl-2 proteins in cancer cells, thus determining the susceptibility of such cells to a new class of anticancer drugs that targets the Bcl-2.
Bcl-2 is considered to be an anti-apoptosis protein, whi...
Proteomic Method To Predict Risks of Pre-term Birth
in The Biotech Weblog, on January 17, 2007
...
Scientist have developed a new proteomics-based scoring system called "Mass Restricted" (MR) score , based on the concentrations of four protein markers, to determine inflammation in th...
Clearblue® Easy Fertility Monitor Significantly Increase Chances of Conception
in Straightfromthedoc, on January 14, 2007
... predictors only identify two fertile days, and other conception methods (e.g. basal Body, Salivary Ferning), monitor the effects of changing hormones and not the hormone levels themselves.]
L...
Biomarkers for Breast Cancer Metastasis
in The Biotech Weblog, on December 18, 2006
Two proteins highly associated with the spread of breast cancer into neighboring lymph nodes have been detected . Although yet unidentified, scientists speculate that these proteins are thymosin beta-10 , a peptide that has already been associated with out-of-control growth and cell diff...
Protein Biomarkers for Alzheimer's Disease
in The Biotech Weblog, on December 14, 2006
... (10 with AD, and 18 healthy subjects), a much larger trial is underway.
Researchers say that this proteomics-based diagnostic panel could not only aid in the early detection and diagnosis of AD, but...
Yeast Model As Tool For Alzheimer's Disease Drug Discovery
in The Biotech Weblog, on November 29, 2006
Scientists re exploring the use of a yeast model as a tool in screening drug candidates that may be treat Alzheimer's Disease (AD) during its early stages. The model is based on the findings that AD is characterized by formation of beta-amyloid plaques in the brain.
"We've develope...
New Technique for the Rapid Analysis of Bioactive Oligosaccharides in Breast Milk
in The Biotech Weblog, on November 28, 2006
Recently, we have seen a lot of research on identifying and reproducing therapeutic compounds in breast milk , such as lactoferrin and lysozymes . This time, researchers from the University of California-Davis and Agilent Technologies have developed a technique combining the used of ...
Using Proteomics To Detect Cancer in Dogs
in The Biotech Weblog, on November 23, 2006
British biotech company, PetScreen Limited has developed an innovative screening and treatment optimisation programme for canine lymphoma , which accoutns for 20% of cancers in high-risk breeds. This is the first of its kind to be made commercially available.
PetScreen has developed the...
Three Protein Biomarkers Predict Chronic Lung Transplant Rejection
in The Biotech Weblog, on November 3, 2006
...on.
These findings were published will be presented during the ongoing Physiological Genomics and Proteomics of Lung Disease Conference . Further research aims to determine what role these proteins ...
Matrix Metalloproteinase Enzyme Degrades Amyloid Fibrils Typical of Alzheimer's Disease
in The Biotech Weblog, on October 25, 2006
Scientists have identified a naturally occurring enzyme called matrix metalloproteinase 9 (MMP-9) , that can break down abnormally aggregated proteins known as amyloid fibrils a key component of the brain plaques characteristic of Alzheimer's disease.
In a new study, appearing Oc...
World's First Allergy Free Cat
in Cool Picking, on October 18, 2006
...etic theraphy, scientist have been able to alter the proteins secreted by cats in their fur, salivary glands and skin that are the cause of most allergic reaction. Thanks to the company Allerca...
Engineered Interleukin-1 Receptor Antagonist For Osteoarthritis
in The Biotech Weblog, on October 16, 2006
Interleukin-1 receptor antagonists is a class of drugs commonly used to treat autoimmune diseases. It has limited application in treating osteoarthritis , the most common form of arthritis, however, as it rapidly breaks down before reaching the joint space. Scientists have therefore attempted ...
Scientists Identify Skin Stem Cell Regulator
in The Biotech Weblog, on October 9, 2006
scientists have identified a protein that acts as a regulator and prevent skin stem cells from maturing into epidermal, sebaceous or hair cells.
"When we compared the list of genes that Tcf3 repressed or induced, we found that it was very similar to the genes expressed when the s...
GRK2 Protein: Biomarker for Heart Failure
in The Biotech Weblog, on September 20, 2006
Thomas Jefferson University researchers have identified a protein which may be a potential biomarker for heart failure . In a study presented during the 10th Annual Scientific Meeting of the Heart Failure Society of America in Seattle last week, white blood cell samples from 20 heart failure ...
Melatonin May Treat Periodontal Diseases
in The Biotech Weblog, on September 15, 2006
... may be potentially valuable in the treatment of periodontal diseases.
"Patients with higher salivary and melatonin ratios had lower community periodontal index (CPI). CPI is the score used to ...
High-Sensitivity Blood-Based Detection of Breast Cancer Using Multi Photon Detection Diagnostic Proteomics
in The Biotech Weblog, on August 30, 2006
An international group of researchers are making progress in the development of a highly sensitive diagnostic test for breast cancer . According to preliminary clinical trials, the new immunoassay using multiphoton-detection (IA/MPD) has been demonstrated to be 200-1000 times more sensitive t...
New Allergy Test: Protein Chip Multiplex Assay
in Allergies, on May 24, 2006
After the allergy skin -test photo I recently posted, I was relieved to read about a firm receiving a Grant from the National Institutes of Health to develop a more rapid, and more importantly, less intimidating, test to diagnose respiratory allergies.
"GenTel's new allergy ...
Merck Acquires GlycoFi and Abmaxis for $480 Million
in The Biotech Weblog, on May 10, 2006
Pharmaceutical company Merck is definitely expanding its biologics protfolio. The firm just acquired two biotech companies: GlycoFi, Inc. and Abmaxis, Inc .
lebanon -based GlycoFi boasts of a proprietal yeast glycoengineering technology that has potential use in developing novel ...
Mumps Testing at the University of Nebraska
in Straightfromthedoc, on April 20, 2006
...duced immunity in students in a university setting.
Mumps is a contagious viral infection of the salivary glands which has affected more than 800 patients in Iowa alone. For more information about ...
Nanogen Inc. Granted Two New Patents on Proteomics and Diagnostics
in The Biotech Weblog, on April 18, 2006
...es and cardiac disease.
"These patents are the result of discoveries that were made in our proteomics research programs," said Howard C. Birndorf, Nanogen chairman and chief executive of...
Cell Surface Profiling Technique: Potential Cancer Blood Test
in The Biotech Weblog, on April 14, 2006
A paper published recently at the Proceedings of the National Academy of Sciences (PNAS) discussed two methods for rapidly profiling cellular ligands and receptors such as what are referred to as O-linked glycoproteins on animal cell surfaces. Changes in these molecules are correlated to ca...
Studying Tyrosine Kinase Src and Cancer Drug Discovery
in The Biotech Weblog, on March 10, 2006
Researchers from John Hopkins identified a novel method to study tyrosine kinase Src , an important protein implicated in cancer. An inactivated, mutated version of the Src protein, which could again be rendered functional by a small molecule called imidazole , was inserted into live animals. A...
Nutrigenomics: Science Fact or Fiction?
in The Biotech Weblog, on March 4, 2006
...al research have been historically geared towards metabolites. The applications of transcriptomics, proteomics and metabolic technologies in nutritional studies are innumerable when it comes to basic ...
Breast Cancer 1000 Library: Using Proteomics' Potentials In Drug Development
in The Biotech Weblog, on February 15, 2006
Harvard Medical School investigators have created the first publicly-available library of reliably expressible proteins in breast cancer. By selecting and expressing a subset of the 1,300 protein-expressing complementary DNAs in the library in a model, they identified novel functions ...
proteomic analysis: a novel diagnosis of preeclampsia
in Straightfromthedoc, on February 7, 2006
...rofessor in the Department of Obstetrics, Gynecology & Reproductive Sciences.
The team applied proteomics to define the best combination of urinary biomarkers that set PE apart from other protein...
Amniotic Fluid Protein Profiling Identifies Infection and Pre-term Birth Risk
in The Biotech Weblog, on February 6, 2006
A study conducted by medical specialists from the Yale University and the University of Kansas School of Medicine revealed that potentially dangerous infections in pregnant women and the probability of premature delivery can be detected by profiling certain proteins present in the amniotic ...
US DA and DOE To Sequence Soybean DNA
in The Biotech Weblog, on January 18, 2006
The US Departments of Agriculture and Energy will collaborate to study plant and microbial genomics.
"Both agencies will leverage their expertise and synergize activities involving agricultural- and energy-related plants and microbes," said Dr. Ari Patrinos, Department of Energy Assoc...
Predicting Protein Folding Hotspots And Drug Discovery
in The Biotech Weblog, on December 19, 2005
A number of diseases are associated with protein aggregation and the formation and accumulation of amyloid fibers , including Parkinson's, Alzheimer's and Creuzfeldt-Jacob disease, as well as pancreatic insufficiency, which causes type 2 diabetes.
Scientists from the Universitat ...
Botox: Beyond Wrinkles And Sweat
in The Biotech Weblog, on December 15, 2005
...of sweat/saliva/mucus and its applications in Hailey--Hailey disease, facial eccrine hidrocystomas, salivary fistulas, and intrinsic rhinitis
Source: ScienceDaily ...
Top Bioscience Issues For 2005
in The Biotech Weblog, on December 5, 2005
With 2005 drawing to a close, The Scientist lists the 5 biggest stories in bioscience this year:
1. Korean stem-cell authority, Woo-Suk Hwang, his cloned dog, Snuppy, his research team's derivation of patient-specific embryonic stem cells via somatic cell nuclear transfer, and the...
Novel Anti-freeze Proteins From Snow Fleas
in The Biotech Weblog, on October 25, 2005
Researchers from Queen's University may have discovered a means to prolong the preservation period for organs for transplantation. Using a process called ice affinity purification , the researchers were able to isolate a novel antifreeze glycine-rich protein from snow fleas. The results ...
Patenting Human Genes
in The Biotech Weblog, on October 17, 2005
A recent acticle in Science (subscription required) estimates the number of patented humand genes at around 4,382, of the total of 23,688 human genes identified so far. According to the Personal Genome blog ,
"While most patented genes have only one IP claim on them, some genes ...
Dr. John Furber, Legendary Pharmaceuticals, Crosslinking Proteins and Aging
in The Biotech Weblog, on September 27, 2005
...make a long story short, John says, "New understandings in the sciences of Genetics, Genomics, Proteomics, Cell Biology and the Physiology of Aging are combining with new capabilities in the tech...
BioVisioN AG and Abbott Sign Research Agreement
in The Biotech Weblog, on September 13, 2005
... Voegeli, Chief Business Officer of BioVisioN AG, says:
"Our early activities in the area of proteomics and peptidomics are now paying off. We are the world leader in peptide biomarker discove...
Latest buzz on the West Nile Virus
in Straightfromthedoc, on September 8, 2005
...ed when they feed on birds infected with West Nile virus. The virus then sits in the mosquito's salivary glands. When an infected mosquito bites a human to take in blood, the virus may be injected...
Peakadilly Receives Patents for Protein Biomarker Discovery Technologies
in The Biotech Weblog, on August 19, 2005
The patent offices of the United States of America and Canada have granted patents for Peakadilly 's core technology, COFRADIC�. COFRADIC� allows the identification and quantification of proteins in any biological sample and represents the most important component of the company'...
Aging Genes Identified
in The Biotech Weblog, on July 28, 2005
...in worms, at least. Using RNAi screening, researchers have identified 23 new longevity genes by screening the genome of Caenorhabditis elegans , a favorite model animal of geneticists. Among the 23 genes that appears to reduce longevity are also involved in insulin signaling, metabolism, a...
