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Results for proteomics bioinformatics. Search took 0.23 seconds.
Anti-Inflammatory Constituents of Ginseng Identified
in The Biotech Weblog, on May 16, 2009
© centralasian Scientists have identified immunologically active components in ginseng, an herb used in traditional Chinese and other Asian medicine.
Allan Lau led a team of researchers from the University of Hong Kong who identified seven ginseng constituents, ginsenosides , which showed imm...
Prognostic Test for Frontotemporal Dementia
in The Biotech Weblog, on March 10, 2009
Photo courtesy of iStockphoto , Image# 6952418 A blood test has been developed to predict the risks of frontal lobe dementia (Frontotemporal Dementia, FTD), a form of dementia that occurs most frequently in patients younger than 65. The test is based on previous findings showing that a genetic d...
200,000 Rice Mutants Available for Study
in The Biotech Weblog, on March 6, 2009
Photo courtesy of iStockphoto , Image# 4796039 Scientists are organizing a repository of genetically modified rice plants in the hope of understanding the function of the approximately 57,000 genes that make up the rice genome. Two hundred thousand rice mutants are now available and have been ...
Brain Enzyme Regulates Appetite and Weight Gain
in The Biotech Weblog, on December 14, 2008
Scientists have determined that an enzyme in the brain called p70 S6 Kinase 1 or S6K may play a role in preventing weight gain and obesity. The researchers injected rats with special viruses that selectively raise or lower S6K activity and found that an increased S6K activity led to reductio...
Biomarkers for Oral Cancer in Saliva
in The Biotech Weblog, on September 30, 2008
...t; Hu said. "We have demonstrated a new approach for cancer biomarker discovery using saliva proteomics ."
Researchers are currently working on a device to detect these biomarkers, a po...
Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)
in The Biotech Weblog, on September 11, 2008
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Photo courtesy of iStockphoto, Rob Broek Researchers have identified proteins in urine samples which may be used as an indicator of the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.
The scientists analysed the proteins in urine samples taken from ...
Netzwerke der Zellen: Toponomik, neues Forschungsgebiet
in Das Gesundheits-Weblog, on August 18, 2008
Da will ich doch gleich noch etwas Neues bieten. ein ganz neues Forschungsgebiet, und das ist nun wirklich Grundlagenforschung im engeren Sinne: oder haben Sie schon etwas von Toponomik gehört? Bisher steht es noch nicht einmal in wikipedia (vielleicht sollte ich einen Eintrag schreiben?* was für m...
Use of Genomics to Control Dandruff
in The Biotech Weblog, on May 23, 2008
...ontracting with Integrated Genomics in Chicago to sequence the entire genome of M. globosa. P&G bioinformatics expert Jun Xu's analysis revealed that the M. globosa genome was tiny, consisting...
RCSB Protein Data Bank Archives 50,000th Molecule Structure
in The Biotech Weblog, on April 10, 2008
The backbone structure of the infectious epsilon15 virus (PDB ID 3c5b, in photo) is the most recent addition to the Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, making it the 50,000th molecule structure released into the only worldwide repository for the three-...
Salivary Proteomics as a Diagnostic Tool
in The Biotech Weblog, on March 26, 2008
...ing the "complete" salivary proteome , a set of proteins in human ductal saliva.
Saliva proteomics and diagnostics is part of a nationwide effort to create the first map of every human pro...
Two Protein Receptors Control Stomach Relaxation Identified
in The Biotech Weblog, on March 5, 2008
Scientists have identified 2 protein receptors in a guinea pig - P2Y1 and P2Y11 - that relax the gut and thus allow it to accommodate a bigger meal. these receptors are also present in humans and may serve as targets for developing drugs to aid in weight management and preventing obesity.
Dr Br...
Natural Products Discovery and Production
in The Biotech Weblog, on February 25, 2008
...throughput screening, genome shuffling, defined media, novel instrumentation, bioreactor operation, bioinformatics, etc., will be discussed within the context of key cultures.
Developments will be ex...
World's Biggest Mathematical Simulation of the Heart
in The Biotech Weblog, on January 20, 2008
... Using bioinformatics and supercomputers , University of Montreal researchers were able to create the largest-ever mathematical simulation of the electrical activity of a human heart - a 2 bil...
Osteocrin Protein Controls Bone Growth
in The Biotech Weblog, on December 23, 2007
Researchers have discovered protein that controls bone growth, and thus may be used as the basis for finding treatment for people with bone diseases affecting skeletal growth.
Osteocrin is a small protein produced by the body's bone-forming cells, or osteoblasts. In this study, mice...
The Human Microbiome Project
in The Biotech Weblog, on December 22, 2007
The National Institutes of Health (NIH) today announced the official launch of the Human Microbiome Project , the collective genomes of all microorganisms present in or on the human body.
Part of the NIH's Roadmap for Medical Research, the Human Microbiome Project will award a total of $1...
Silk from Bees
in The Biotech Weblog, on November 29, 2007
Did you know that, like moths, spiders butterflies and silkworms, bees also produce silk?
Those are the latest findings reported recently in Molecular Biology and Evolution , which discusses the honeybee silk genes and the properties of the coil proteins from the cocoon and nest silk...
Novel D-Peptides More Potent Against HIV
in The Biotech Weblog, on October 11, 2007
Scientists at the University of Utah have developed new peptides that appear to be significantly more effective at blocking HIV's entry into cells than other drugs in their class.
"Our 'D-peptides' offer several potential therapeutic advantages over existing peptide entry inhi...
Progranulin Deletion or Mutation Leads to Toxic Proteins Build-up in Neurons
in The Biotech Weblog, on September 28, 2007
Researchers have discovered that a deletion of a gene for progranulin leads to the accumulation of toxic proteins in the brain which subsequently results to dementia.
In the Sept. 26 issue of the Journal of Neuroscience, the scientists demonstrate that absence of a gene known as progranulin lead...
Lab-on-a-Chip Device for Detecting Avian Flu
in The Biotech Weblog, on September 25, 2007
Researchers have developed a miniaturized device which can detect the highly pathogenic avian flu (H5N1) virus in throat swab samples, with results released within half an hour.
The device comprises a unique platform that uses magnetic force to manipulate individual droplets containing si...
Protein Biomarkers for Colorectal Cancer Identified
in The Biotech Weblog, on September 24, 2007
Using two-dimensional gel electrophoresis and mass spectrometry, 27 differentially expressed protein biomarkers for colorectal adenoma have been identified . The differential expression of two of these novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validat...
ACuRay™ Acoustic Sensor for Cancer
in The Biotech Weblog, on September 21, 2007
Researchers from the Georgia Institute of Technology have created ACuRay ™ (stands for standing for ACoustic micro-arRay), an acoustic sensor that can detect small amounts of mesothelin , a molecule associated with a number of cancers including mesothelioma. The device consists of an array of e...
Pepfactant® Switchable Peptide Surfactant
in The Biotech Weblog, on August 22, 2007
(Photo: The tube on the left shows the original emulsion, while the one on the right shows the rapid separation of the emulsion into oil and water after a newly developed "switchable" detergent is added. Credit: Annette dexter , University of Queensland)
Researchers have develop...
Anti-Diabetes Drug Candidate Liraglutide Improves Glucose Control and Lowers Body Weight
in The Biotech Weblog, on August 21, 2007
Two Phase III clinical trials involving more than 2000 patients have shown that Novo Nordisk's new anti-diabetes drug candidate liraglutide have a positive effect on blood glucose control, body weight and hypoglycaemia risks. Liraglutide is a once-daily human analogue of the naturally occurr...
ESF EURYI Awardee Tackles Topoisomerases to Control Cancer Growth
in The Biotech Weblog, on August 10, 2007
One of this year's ESF EURYI award winning projects explores a new line in anti-cancer therapy by blocking the molecular motors involved in copying genetic information during Cell division , which may be used to complement existing cancer therapies.
Dekker is focusing on an enzyme ...
Bone as Therapeutic Target for Type 2 Diabetes
in The Biotech Weblog, on August 10, 2007
A new study published in the August 10 issue of Cell indicates that the skeleton is not just for structural support, but also helps control sugar metabolism and weight and is thus a major determinant of the development of type 2 diabetes. Apparently, bone cells release a hormone called os...
REST Protein May Halt Cardiac Hypertrophy
in The Biotech Weblog, on June 6, 2007
Researchers have discovered that the progression of cardiac hypertrophy can be halted by increasing one of the body's naturally occurring proteins known as REST. Cardiac hypertrophy is a relatively common condition characterized by an abnormal thickening of the heart muscle.
Dr Ooi&...
Google Invests $39M in Biotech Start-up on Personal Genetics
in The Biotech Weblog, on May 24, 2007
Google has invested $39 million in 23andme , a privately held, early-stage personal genetics company co-founded by Anne Wojcicki, who is married to Google, Inc. co-founder Sergey Brin.
From the 23andme website:
Even though your body contains trillions of copies of your genome, you've lik...
New Method for Identifying Marine Microorganisms
in The Biotech Weblog, on May 23, 2007
Researchers from the Bigelow Laboratory for Ocean Sciences report of a new approach in identifying unculturable microorganisms from marine environments .
"We present a novel approach to studying metabolic capabilities of the uncultured microbial taxa. Our method is based on fluorescence...
Antibody Developed to Detect Mutant Enzyme Causing Amyotrophic Lateral Sclerosis
in The Biotech Weblog, on May 14, 2007
Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig 's disease, is a progressive and usually fatal neurological disorder that attacks the nerves and muscles. Researchers have now developed the first antibody that detects misfolded conformations of the enzyme superoxide-dimutase-1...
Blood Test for the Early Diagnosis of Parkinson's Disease
in The Biotech Weblog, on April 28, 2007
A new blood test to diagnose Parkinson's disease (PD) before symptoms appear has been developed. The test measures the blood concentration of a brain-secreted protein called ' alpha-synuclein ', which is found to be low in PD patients.
"Currently there is no specific PD diag...
Saving Science From Itself
in Philoneist, on April 10, 2007
...now the difference between biochemistry, geochemistry, biogeochemistry and paleobiogeochemistry and bioinformatics. But for your average professional who itches his or her scalp in curiosity while rea...
Metabolomics and Nutrigenomics Symposium
in The Biotech Weblog, on March 6, 2007
...t -gene interactions, the use of metabolomics and nutrigenomics as clinical tools, and how bioinformatics can facilitate new discoveries. Approximately 300 researchers in the field are expec...
Biomarker Test for Bladder Cancer Recurrence and Survival
in The Biotech Weblog, on February 20, 2007
A new diagnostic test has been developed to better predict the recurrence and survival of bladder cancer patients. The test is based on the presence of molecular biomarkers Bcl-2 , caspase-3 , P53 and survivin -- proteins known to regulate apoptosis, or programmed cell death.
[snip] .....
Phorecaster: Forecasting Tool Could Reduce Drug Development Costs
in The Biotech Weblog, on February 14, 2007
A teams of researchers from the Children's Hospital Boston Informatics Program (CHIP) has developed a forecasting model called Phorecaster , to predict the probability that a given new drug would pass successfully through Phase III trials and receive New Drug Application (NDA) approval.Th...
The Diabetes Genetics Initiative
in The Biotech Weblog, on February 13, 2007
The Broad Institute, Lund University and Novartis have announced the completion of a genome-wide map of genes related to type 2 diabetes and other metabolic disorders.
Driven by recent advances in the knowledge of human genetic variation, high-throughput genomic technologies, and computa...
Horse Genome Sequence Database Now Publicly Accessible
in The Biotech Weblog, on February 12, 2007
The first draft of the horse genome sequence is now publicly available for use by biomedical and veterinary researchers around the globe.
In addition to sequencing the horse genome, researchers produced a map of horse genetic variation using DNA samples from a variety of modern and ancestral...
Protein Biomarkers Predict Bladder Cancer Recurrence and Survival
in The Biotech Weblog, on February 6, 2007
Based on the analysis of archival tissue from 226 patients who underwent surgery for bladder cancer, scientists were able to identify four protein biomarkers that could predict the recurrence of bladder cancer . The findings, which researchers say could one day alter the postoperative treatment...
In Silico Screening of Chinese Herbs Using Random Forest
in The Biotech Weblog, on January 25, 2007
Researchers from the King's College London have conducted the first large-scale computer screenings of chinese herbs , which revealed a wide variety of compounds with potential for use in treating HIV/AIDS, cancer, Alzheimer's Disease, arthritis and other diseases. They used Random...
BH3 Profiling Determines Sensitivity to Experimental Cancer Drug
in The Biotech Weblog, on January 23, 2007
Researchers have developed a test called "BH3 profiling" to determine the levels of the Bcl-2 proteins in cancer cells, thus determining the susceptibility of such cells to a new class of anticancer drugs that targets the Bcl-2.
Bcl-2 is considered to be an anti-apoptosis protein, whi...
Proteomic Method To Predict Risks of Pre-term Birth
in The Biotech Weblog, on January 17, 2007
...
Scientist have developed a new proteomics-based scoring system called "Mass Restricted" (MR) score , based on the concentrations of four protein markers, to determine inflammation in th...
Biomarkers for Breast Cancer Metastasis
in The Biotech Weblog, on December 18, 2006
Two proteins highly associated with the spread of breast cancer into neighboring lymph nodes have been detected . Although yet unidentified, scientists speculate that these proteins are thymosin beta-10 , a peptide that has already been associated with out-of-control growth and cell diff...
Protein Biomarkers for Alzheimer's Disease
in The Biotech Weblog, on December 14, 2006
... (10 with AD, and 18 healthy subjects), a much larger trial is underway.
Researchers say that this proteomics-based diagnostic panel could not only aid in the early detection and diagnosis of AD, but...
GreeneChip DNA Chip for Detection of Pathogens
in The Biotech Weblog, on December 7, 2006
Scientists have developed a new diagnostic device that can potentially identify thousands of different pathogens from human samples.
Called the "GreeneChip," this device consists of a glass slide onto which are attached nearly 30,000 pieces of genetic material taken from thousands of ...
Yeast Model As Tool For Alzheimer's Disease Drug Discovery
in The Biotech Weblog, on November 29, 2006
Scientists re exploring the use of a yeast model as a tool in screening drug candidates that may be treat Alzheimer's Disease (AD) during its early stages. The model is based on the findings that AD is characterized by formation of beta-amyloid plaques in the brain.
"We've develope...
New Technique for the Rapid Analysis of Bioactive Oligosaccharides in Breast Milk
in The Biotech Weblog, on November 28, 2006
Recently, we have seen a lot of research on identifying and reproducing therapeutic compounds in breast milk , such as lactoferrin and lysozymes . This time, researchers from the University of California-Davis and Agilent Technologies have developed a technique combining the used of ...
Using Proteomics To Detect Cancer in Dogs
in The Biotech Weblog, on November 23, 2006
British biotech company, PetScreen Limited has developed an innovative screening and treatment optimisation programme for canine lymphoma , which accoutns for 20% of cancers in high-risk breeds. This is the first of its kind to be made commercially available.
PetScreen has developed the...
Two-Component Lantibiotic Haloduracin From Bacillus halodurans
in The Biotech Weblog, on November 1, 2006
...slationally modified to an active form, and act in synergy to provide antibacterial activity. Using bioinformatics, the researchers used genes from the gram -positive bacterium Bacillus halodur...
Mouse Resequencing and SNP Discovery Project Completed
in The Biotech Weblog, on October 26, 2006
A recently completed DNA sequencing of the 15 mouse strains most commonly used in biomedical research showed that there were more than 8.3 million single nucleotide polymorphisms (SNPs) in their genomes. These data will help researchers understand and possibly identify potential therapeutic ...
Matrix Metalloproteinase Enzyme Degrades Amyloid Fibrils Typical of Alzheimer's Disease
in The Biotech Weblog, on October 25, 2006
Scientists have identified a naturally occurring enzyme called matrix metalloproteinase 9 (MMP-9) , that can break down abnormally aggregated proteins known as amyloid fibrils a key component of the brain plaques characteristic of Alzheimer's disease.
In a new study, appearing Oc...
Engineered Interleukin-1 Receptor Antagonist For Osteoarthritis
in The Biotech Weblog, on October 16, 2006
Interleukin-1 receptor antagonists is a class of drugs commonly used to treat autoimmune diseases. It has limited application in treating osteoarthritis , the most common form of arthritis, however, as it rapidly breaks down before reaching the joint space. Scientists have therefore attempted ...
Scientists Identify Skin Stem Cell Regulator
in The Biotech Weblog, on October 9, 2006
scientists have identified a protein that acts as a regulator and prevent skin stem cells from maturing into epidermal, sebaceous or hair cells.
"When we compared the list of genes that Tcf3 repressed or induced, we found that it was very similar to the genes expressed when the s...
GRK2 Protein: Biomarker for Heart Failure
in The Biotech Weblog, on September 20, 2006
Thomas Jefferson University researchers have identified a protein which may be a potential biomarker for heart failure . In a study presented during the 10th Annual Scientific Meeting of the Heart Failure Society of America in Seattle last week, white blood cell samples from 20 heart failure ...
High-Sensitivity Blood-Based Detection of Breast Cancer Using Multi Photon Detection Diagnostic Proteomics
in The Biotech Weblog, on August 30, 2006
An international group of researchers are making progress in the development of a highly sensitive diagnostic test for breast cancer . According to preliminary clinical trials, the new immunoassay using multiphoton-detection (IA/MPD) has been demonstrated to be 200-1000 times more sensitive t...
Entelos Collaborates With Novartis On In Silico Drug Trials
in The Biotech Weblog, on August 23, 2006
Before drugs make it to the commercial production, they are first tested in vitro i.e., under laboratory conditions. And then they go through in vivo , or clinical trials involving animal and ultimately, human models. But in between these two stages, did you know that there is also an optional...
New Allergy Test: Protein Chip Multiplex Assay
in Allergies, on May 24, 2006
After the allergy skin -test photo I recently posted, I was relieved to read about a firm receiving a Grant from the National Institutes of Health to develop a more rapid, and more importantly, less intimidating, test to diagnose respiratory allergies.
"GenTel's new allergy ...
Merck Acquires GlycoFi and Abmaxis for $480 Million
in The Biotech Weblog, on May 10, 2006
Pharmaceutical company Merck is definitely expanding its biologics protfolio. The firm just acquired two biotech companies: GlycoFi, Inc. and Abmaxis, Inc .
lebanon -based GlycoFi boasts of a proprietal yeast glycoengineering technology that has potential use in developing novel ...
ENDEAVOUR: Computer Program For Identifying Disease Genes
in The Biotech Weblog, on May 10, 2006
Researchers from ESAT-SCD (Engineering Sciences) and the Flanders Interuniversity Institute for Biotechnology (VIB) have developed ENDEAVOUR , a computer program that compiles and processes data from a variety of databases and identifies the genes that play a key role in a particular geneti...
