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Seen that? - Diabetes Challenges: Dealing With Diabetes On Valentine's Day
in Daily Diabetic, on October 21, 2009
...iation (ADA) will [...] Read More Merck KGaA Licenses Glenmark Pharmaceuticals' DPPIV Inhibitor for Type 2 Diabetes at The Biotech Weblog Me...
Pregnancy and Antidepressants
in Well Woman Blog, on August 22, 2009
...an antidepressant at some point during her pregnancy.
Greater use of selective serotonin reuptake inhibitor (SSRI) antidepressants like Prozac, Paxil, and Zoloft were largely responsible for the incr...
Onglyza: New Diabetes Drug, Approved By The FDA
in Daily Diabetic, on August 2, 2009
...nce-daily tablet that lowers high blood sugar levels.
Onglyza is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
DPP-4 inhibitors affect the action of incretins, hormones that decrease elevated blood...
OTC Prevacid®, Heartburn Medicine Now FDA-Approved
in Straightfromthedoc, on May 15, 2009
...A recently announced its approval of Prevacid® 24HR, the first over-the-counter (OTC) Proton Pump Inhibitor (PPI) for the treatment of frequent heartburn approved in the US since 2003. Prevacid 24HR i...
Drug Combo May Lower Diabetics' Kidney Risk
in Daily Diabetic, on February 19, 2009
... of iStockphoto , Image# 5917289
A two-drug combination of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the diuretic indapamide, reduced the risk of kidney disease by about 20 pe...
RHAMM Protein Removes Wrinkles
in The Biotech Weblog, on February 13, 2009
...;Unlike neurotoxin agents, which have to be injected periodically, a localized injection of a RHAMM inhibitor should produce long-lasting skin volumizing effects and would not involve muscle paralysis...
FDA Approves Savella for treatment of Fibromyalgia
in The Biotech Weblog, on January 16, 2009
... , Inc. and Cypress Bioscience, Inc. , is a selective serotonin and norepinephrine dual reuptake inhibitor.
Two US phase III clinical trials involving over 2,000 patients with fibromyalgia have sho...
Leukemia Drug May Treat Type-1 Diabetes
in The Biotech Weblog, on November 20, 2008
...nd even reverse type 1 diabetes .
[snip] they found that treating mice with Imatinib or a similar inhibitor drug for seven weeks before the onset of auto-immune (type 1) diabetes prevented developm...
LEV Pharma's Cinryze™ Got FDA Marketing Approval For HAE
in Straightfromthedoc, on October 13, 2008
...and life threatening disease, hereditary angioedema (HAE) is an autosomal dominant disorder of C1 inhibitor (C1-INH) deficiency manifested by painless, nonpruritic, nonpitting swelling of the skin.
...
Durchbruch bei Alzheimer?
in Das Gesundheits-Weblog, on 30.09.08
....
In Mäuseversuchen hat man jetzt einen Wirkstoff gefunden, der auf QC hemmend wirkt (sog. Inhibitor ). Damit wäre aus Sicht der Forscher eine echte Kausaltherapie der Alzheimer-Krankheit möglich,...
Nielsen Mobile: More Texting Than Talking
in The Wireless Weblog, on September 29, 2008
...ot;
Wired's Meghan Keane notes that this is good news for mobile advertisers. "A major inhibitor to mobile advertising campaigns in the American market has been cellphone users' slow ...
Use of Genomics to Control Dandruff
in The Biotech Weblog, on May 23, 2008
..., 127:2138-46, 2007). The chemical engineers capitalized on this discovery by synthesizing a lipase inhibitor, which they soon tested on human subjects. Dawson refuses to disclose how much improvement...
Chromium Ingredient May Lower Blood Pressure
in Straightfromthedoc, on May 15, 2008
... health.
Results of the new study indicate that niacin-bound chromium III (NBC) may act as an ACE inhibitor, which work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, a...
Stressed? Try Vanilla
in Latina Viva, on May 1, 2008
... DNA repair promoted by properties found in vanilla. It's being studied as a potential cancer inhibitor .
If you're a chocolate lover (like me), you're in luck, because most chocolate ...
Anti-Cancer and Anti-Migraine Drug Candidates Purified from Plants
in The Biotech Weblog, on April 23, 2008
... able to isolate and purify potential an anti-cancer drug candidate and a neurogenic vasodilatation inhibitor (for the treatment of migraine), from the plants Baccharis latifolia , and elecampe ( Dit...
Novartis Diabetes Drug Eucreas, EU-Approved
in Daily Diabetic, on February 25, 2008
... approved by The European Union for type 2 diabetes . Eucreas is a combination of Galvus (a DPP-4 inhibitor) and metformin (a popular diabetes drug which decreases the production of sugar by the liv...
Welchol™ (colesevelam HCl), FDA-Approved for Glycemic Control in Type 2 Diabetes
in Daily Diabetic, on January 21, 2008
...herapy or in combination with an hydroxymethyl-glutaryl- coenzyme A (HMG CoA) reductase inhibitor.
Also, Welchol™ is indicated as an adjunct to diet and exercise to improve glycemic control in ...
Takeda Filed for US Approval of Diabetes Drug Alogliptin
in Daily Diabetic, on January 4, 2008
..., or SYR-322, is in a new class of oral agents for the treatment of type 2 diabetes, called DPP-4 inhibitor , regulating blood glucose levels, and the class also includes Merck & Co's Ja...
Nexavar® (sorafenib), FDA-Approved for Inoperable Hepatocellular Carcinoma
in Straightfromthedoc, on November 21, 2007
... (Emeryville, California) - Nexavar® (sorafenib) - is a type of anticancer drug called a kinase inhibitor that interferes with molecules that are thought to be involved in chemical messages sent wit...
Diabetes Drug Januvia Has New FDA-Approved Uses
in Daily Diabetic, on October 26, 2007
...herapy with certain other drugs, such as metformin and thiazolidinediones .
Januvia is a DPP-4 inhibitor: it inhibits glucagon production (the enzyme that increases blood sugar), and stimu...
Heparanase Inhibitor, Potential Anti-Cancer Drug Candidate
in The Biotech Weblog, on October 23, 2007
...ious studies to malignancy. A recent study published in Nature Chemical Biology indicates that an inhibitor for heparanase may have potentials as an anti-cancer drug candidate.
Heparanase helps can...
Novartis Diabetes Drug Galvus, EU-Approved for Type 2 Diabetes
in Daily Diabetic, on October 1, 2007
...ug.
Galvus (vildagliptin) is a once-daily oral treatment for type 2 diabetes: a DPP-4 inhibitor that works by targeting the dysfunction in the pancreatic islets that causes high blood-s...
Protein Plaques and Type 2 Diabetes
in Daily Diabetic, on September 13, 2007
...9;s structure transformed it from one of the most potent amyloid-forming substances into a powerful inhibitor of amyloid formation.
In laboratory studies, they showed that the mutant IAPP significant...
ED Pills Don't Solve All Erectile Problems
in Straightfromthedoc, on July 12, 2007
... The oral medications known as PDE5 inhibitors - like Viagra® and the likes - may restore a man's sexual function but don't necessarily restore a man's sexual health.
According to D...
Fibrinogen: Blood-Clotting Protein, Inhibits Spinal Cord Regeneration
in The Biotech Weblog, on July 10, 2007
...growth factor receptor. When the second receptor is activated, it inhibits the axonal growth. Other inhibitors have been identified that use the same epidermal growth factor receptor, but this is the ...
Male Hormones Inhibitor May Cure Hard-to-Treat Prostate Cancer
in Straightfromthedoc, on July 9, 2007
A new drug candidate that inhibits production of male hormones anywhere in the body - abiraterone - is showing potential in early trials on prostate cancer patients whose tumors continued to grow despite medical or surgical intervention.
As presented last week at the ESMO Conference Lu...
HDAC Inhibitors: Cancer Drug, Can Enhance Long-term Memory
in Straightfromthedoc, on June 7, 2007
... Histone deacetylase (HDAC) inhibitors - cancer drugs currently used in clinical trials to attack cancerous tumors - has been found in mice study by UC Irvine scientists to enhance long-term m...
Gene Therapy for Treating Neuropathic Pain
in The Biotech Weblog, on June 4, 2007
...was reversed by the subsequent addition of low concentrations of strychnine, a strong GlyR-specific inhibitor, or antagonist.
The study has been published has been presented at the 10th annual meetin...
ACE-Inhibitor Hypertension Drugs May Help Prevent Alzheimer's Disease
in The Biotech Weblog, on May 11, 2007
...ding to a new study, a class of hypertension medication called angiotensin-converting enzyme (ACE) inhibitors may may help protect older adults from declines in memory and other cognitive function t...
Plant Chemical Harmine, Fights Diabetes without Side Effects
in Daily Diabetic, on May 11, 2007
...ction instead of triggering PPARã directly.
The authors concluded:
"Harmine inhibits an inhibitor for a net positive effect on fat that ultimately appears to restore insulin response without ...
Centrally Active ACE Inhibitors May Help Reduce Risk of Cognitive Decline in Older Adults
in Straightfromthedoc, on May 9, 2007
... Some high blood pressure medicine - especially the types of ACE inhibitors that can reach the brain and may help reduce the inflammation that might contribute to Alzheimer's disease (centra...
ADHD Children Who Start on Strattera® More Likely to Change Therapies, Study Says
in Straightfromthedoc, on April 19, 2007
... in San Diego.
Straterra® , a product of Eli Lilly and Company and a norepinephrine reuptake inhibitor, is the first and only non-stimulant medication approved by the USFDA for the treatment of AD...
DPP-4 Inhibitor JANUVIA® Approved In EU for Type 2 Diabetes
in Daily Diabetic, on March 27, 2007
...in, blood sugar cannot be broken down).
Now, a new class of drugs known as dipeptidyl peptidase-4 inhibitors or DPP-4 inhibitors is capable of enhancing the body's own ability to lower bloo...
FDA Approves Novartis' Hypertension Drug Tekturna
in The Biotech Weblog, on March 8, 2007
... The US FDA has approved Novartis' new hypertension drug, Tekturna (aliskiren), a direct renin inhibitor. A once-daily oral tablet therapy, Tekturna acts by blocking renin, an enzyme responsible ...
FDA Approves the First Drug for Obese Dogs
in The Biotech Weblog, on February 20, 2007
...s.
Slentrol is a new chemical entity, called a selective microsomal triglyceride transfer protein inhibitor, which blocks the assembly and release of lipoproteins into the bloodstream. The mechanism...
Pterostilbene: Berry Compound that Suppresses Cancer-Causing Enzyme
in Straightfromthedoc, on January 5, 2007
... is a berry and grape compound that has been found to have health benefits including being a cancer inhibitor.
Recent findings at the USDA/ARS further supported this claim which found that the comp...
Newest Treatment For Type 2 Diabetes Unleashed
in Daily Diabetic, on December 30, 2006
...pe 2 diabetes. Saxagliptin, discovered by Bristol-Myers Squibb, is a dipeptidyl peptidase-4 (DPP-4) inhibitor currently in Phase III development in the United States and Europe.
Saxagliptin is a dipe...
Bowmann-Birk Inhibitor Concentrate (BBIC) from Soy May Help Treat Multiple Sclerosis
in The Biotech Weblog, on December 14, 2006
...
A preparation from soy called Bowmann-Birk Inhibitor Concentrate (BBIC) appears to dramatically improve mobility and walking of an animal model with multiple sclerosis , and neurologists say th...
ACE Inhibitors May Help Reduce Diabetes Symptoms
in Daily Diabetic, on October 29, 2006
... Another 'off the label' type of medicine is being prescribed to fight diabetes: ACE inhibitors. Originally used to lower blood pressure, these medications seem to have a positive effect o...
DPP-4 Inhibitor by Merck: JANUVIA™, Approved by the USFDA for Type 2 Diabetes
in Straightfromthedoc, on October 20, 2006
... Belonging to a class of class of prescription medications called dipeptidyl peptidase-4 (DPP-4) inhibitors, Merck's JANUVIA™(sitagliptin phosphate ) has recently been approved by the U...
Merck KGaA Licenses Glenmark Pharmaceuticals' DPPIV Inhibitor for Type 2 Diabetes
in The Biotech Weblog, on October 17, 2006
...enmark Pharmaceuticals hve entered into a collaborative agreement to develop Glenmark's DPPIV inhibitor GRC 8200 , a treatment for type 2 diabetes, currently under Phase II clinical development....
Premature Ejaculation Drug: Dapoxetine, Effective and Safe, Study Says
in Straightfromthedoc, on September 12, 2006
... Dapoxetine , a selective serotonin reuptake inhibitor (SSRI) was specifically developed to treat premature ejaculation .
Researchers from the University of Minnesota have shown from a mul...
Merck's VIOXX® Reduces Risk of Colorectal Polyps, Study Found
in Straightfromthedoc, on September 4, 2006
...rsors to colon cancer .
A new Dartmouth clinical trial reported that the cyclooxygenase-2 (COX-2) inhibitor rofecoxib ( VIOXX® ) has been found to reduce the risk of developing colorectal adenomas ...
ACE-Inhibitor Diabetes Prevention Drug Fails In Trial
in Daily Diabetic, on August 30, 2006
... Though researchers had high hopes for the role of the ACE-inhibitor drug ramipril (brand name Altace) in preventing Type 2 diabetes, they had to declare the experiment a bust.
The ACE-inhibitor...
Metrics - How Numbers Can Help You Manage
in Bizinformer, on August 17, 2006
...very effective means of benchmarking at a peer group or industry level.
But metrics can become an inhibitor to progress in the operation should a manager use metrics in a punitive manner. While a ma...
Clinical Trials Begin For New Diabetes Drug
in Daily Diabetic, on July 31, 2006
...ieve the medicine is an innovation in diabetes treatment .
The mechanism of action of DPP-4 inhibitors is distinct from that of any currently available class of glucose lowering agents.
Sitag...
Cardeva™ for Chronic Heart Failure (CHF), Clinical Trial On-going
in Straightfromthedoc, on July 20, 2006
...g duration of action.
"BNP stimulates cyclic GMP, which is not only a vasodilator but an inhibitor of the progressive heart muscle structural remodeling that leads to progression of heart fai...
Rho Kinase Inhibitors May Treat Certain Gastrointestinal Disorders
in The Biotech Weblog, on July 19, 2006
...milar problems involving bowel movement.
Working on mice models, scientists have shown that an ROK inhibitor, Y 27632 alleviating hypertensive IAS. According to the authors of the study to be publi...
Anti-Cholesterol Proteins in Milk
in The Biotech Weblog, on July 4, 2006
...erol market. Currently, Zetia (Schering-Plough/Merck) seems to be the only cholesterol absorption inhibitor drug on this million-dollar market.
Read more from NutraIngredients ....
FDA Approves Exelon For Parkinson Disease Dementia
in The Biotech Weblog, on June 29, 2006
...9;s approval of Exelon helps to fill this medical need."
Exelon is a choline esterase inhibitor , which works by increasing the levels on acetylcholine in the brain. It has already secur...
Nastech To Start Human Clinical Trials on Intranasal Obesity Spray
in The Biotech Weblog, on June 7, 2006
...ork?
Peptide YY is a naturally occurring hormone that is believed to function as a physiologic inhibitor of food intake . PYY is produced by specialized endocrine cells (L-cells) in the gu...
FDA Approves Thalomid For Multipple Myeloma Therapy
in The Biotech Weblog, on May 30, 2006
... for the treatment of certain symptoms associated with Erythema Nodosum Leprosum (ENL) . It is an inhibitor of tumor necrosis factor alpha , and is the best known agent for short-term treatment of E...
Drug Combo Eases Stomach Upset in Arthritis Patients
in Straightfromthedoc, on May 8, 2006
... in combination with Prevacid (acid-reducing). Such, may prove more effective than taking a Cox-2 inhibitor alone like Celecoxib .
Researchers found that compared to taking an over-the-counter an...
Pfizer Acquires Rinat Neuroscience Corp.
in The Biotech Weblog, on April 13, 2006
...hnologies."
Some of the compounds in Rinat's pipeline are RN624 , a nerve growth factor inhibitor for treatment of acute and chronic pain (currently entering Phase II clinical trials) and ...
Anti-Depression Transdermal Patch Approved by FDA
in The Biotech Weblog, on March 8, 2006
... US, where 14 million adults could become candidates for the drug .
Emsam is a monoamine oxidase inhibitor , which, when taken orally, can react with foods such as cheese and processed meats, raisi...
Microbia Raises $75M To Advance IBS Drug Candidate Through Clinical Trials
in The Biotech Weblog, on February 28, 2006
...erapeutics through clinical trials, including both MD-1100 and our Phase 1 cholesterol absorption inhibitor MD-0727, " said Peter Hecht, CEO of Microbia. "Both of these innovative oral dru...
Amgen's Denosumab Increases Bone Mineral Density in Phase 2 Clinical Trials
in The Biotech Weblog, on February 27, 2006
...clinical trials for Denosumab (previously referred to as AMG 162), showing that the RANK Ligand inhibitor significantly increased bone mineral density (BMD) in the total hip, lumbar spine, ...
Botox: Beyond Wrinkles And Sweat
in The Biotech Weblog, on December 15, 2005
...icity and pain alleviation
proctology, and as non-surgical therapy for anal fissure
as an inhibitor of acetylcholine, substance P and glutamate, and its applicability in the treatment of var...
Amgen Acquires Abgenix for $2.2 B
in The Biotech Weblog, on December 15, 2005
...(they will file for FDA approval next week), the drug, which is an epidermal growth factor receptor inhibitor, is expected to have billion dollar potentials. Amgen's press release says that Amgen ...
Novel Antimalarial Drug and Vaccine Candidates
in The Biotech Weblog, on November 28, 2005
... thereby allowing it to invade red blood cells. The researchers were then able to design a specific inhibitor of PfSUB2 which potently prevents shedding of parasite surface proteins, thereby preventin...
Methionyl-tRNA Inhibitor REP8839 Novel Antibiotic Against Staphylococcus
in The Biotech Weblog, on October 21, 2005
...y have discovered a compound that has potential use as a topical antibiotic. A novel methionyl-tRNA inhibitor, REP8839 , proved effective against against Staphylococcus aureus and S. pyogenes , in...
The Excitement Over Lower Tag Prices
in The RFID Weblog, on October 11, 2005
...gh cost of tags and how there is little or no return on that investment, tag prices are not a major inhibitor to adoption at this stage."
What he says makes a lot of sense. In the short term no...
The FDA blocks an injectable COX-2
in Straightfromthedoc, on September 21, 2005
...ency about the rejection.
New York-based Pfizer argues that Dynastat, as the only injectable Cox-2 inhibitor, reduces the need for opioids to control pain after surgery. ...
OSI and Eyetech Merge
in The Biotech Weblog, on August 23, 2005
...ef Executive Officer of OSI Pharmaceuticals.
Their leading products are Tarceva , the first EGFR inhibitor to demonstrate improved survival in both non-small cell lung cancer (NSCLC) and pancreatic...
mTOR Inhibitor Designated as Orphan Drug
in The Biotech Weblog, on August 23, 2005
...
ARIAD Pharmaceuticals, Inc. announced last week that AP23573 , its novel mTOR inhibitor, has been designated an orphan drug by the United States Food and Drug Administration (FDA) for the tr...
The -Omics Series, Part 1: Genomics
in The Biotech Weblog, on August 12, 2005
...he reaction to a particular drug. For example, Iressa , an epidermal growth factor receptor (EGFR) inhibitor designed against non-small-cell lung cancer (NSCLC) works in about 25% of cases in Japan, ...