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Seen that? - Is there hope for female sexual dysfunction?
in Straightfromthedoc, on October 31, 2009
... at Straightfromthedoc The oral medications known as PDE5 inhibitors - like Viagra® and the likes - may restore a man's sexual function but don't nece...
Seen that? - Diabetes Challenges: Dealing With Diabetes On Valentine's Day
in Daily Diabetic, on October 21, 2009
...tor GRC 8200, a treatment for type 2 diabetes, currently under Phase II clinical development. DPPIV inhibitors are a class of drugs that work by inhibiting the activity of the DPP-IV enzyme, thereby s...
Seen that? - Do erectile dysfunction drugs cause blindness?
in Straightfromthedoc, on October 2, 2009
... at Straightfromthedoc The oral medications known as PDE5 inhibitors - like Viagra® and the likes - may restore a man's sexual function but don't nece...
Natural Odors and Development of Mosquito Repellents
in The Biotech Weblog, on August 26, 2009
...t; Ray said. "In our experiments we identified hexanol, and a related odor, butanal, as strong inhibitors of CO2-sensitive neurons in Culex mosquitoes. These compounds can now be used to guide re...
Onglyza: New Diabetes Drug, Approved By The FDA
in Daily Diabetic, on August 2, 2009
...t lowers high blood sugar levels.
Onglyza is a dipeptidyl peptidase-4 (DPP-4) inhibitor.
DPP-4 inhibitors affect the action of incretins, hormones that decrease elevated blood sugar levels (gluco...
Licorice Compound May Prevetn Colon Cancer
in The Biotech Weblog, on March 24, 2009
...ted the development of polyps (adenomas) and tumor growth and metastasis.
Unlike other COX-2 inhibitors currently available, the effects of the licorice compound is specific only to the colon and the...
Egg Proteins May Reduce Blood Pressure
in Straightfromthedoc, on February 21, 2009
...ll intestine to produce peptides with angiotensin converting enzyme (ACE)-inhibitory activity.
ACE inhibitors work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiote...
Chicken Soup Against High Blood Pressure
in Straightfromthedoc, on October 20, 2008
...esearchers .
Apparently, chicken breasts have collagen proteins which have similar effects to ACE inhibitors - the main medications for the treatment of high blood pressure (hypertension).
But sin...
Durchbruch bei Alzheimer?
in Das Gesundheits-Weblog, on 30.09.08
...röffentlichung Daten vor, wonach die orale Gabe (über den Mund) eines QC-Inhibitors bei Nagetieren zu einer deutlichen Verbesserung der Gedächtnisleistung führt. Die Ergebnisse stützen nachdrücklich P...
Chromium Ingredient May Lower Blood Pressure
in Straightfromthedoc, on May 15, 2008
...o the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure.
ACE inhibitors made by drug companies have been found to be beneficial in treating hypertension, particu...
New Molecule May Lead to Anti-Heart Attack Drug
in Straightfromthedoc, on April 21, 2008
...g drugs, could be taken orally.
"RUC-1 could provide advantages over the currently available inhibitors," Blue says. If someone was at very high risk for having a heart attack, he could kee...
Nexium, FDA-Approved for Pediatric GERD
in Straightfromthedoc, on March 4, 2008
...r any adverse drug reactions."
Nexium is part of a class of drugs known as proton pump inhibitors (PPIs). PPIs decrease the amount of acid produced in the stomach and help heal erosions i...
Novartis Diabetes Drug Eucreas, EU-Approved
in Daily Diabetic, on February 25, 2008
...arent - on Feb. 1 after Novartis said the label for the drug should warn for liver problems.
DPP-4 inhibitors enhance the body's own ability to lower elevated blood sugar and could become an impo...
FDA's Safety Reviews: No Evidence That Use of Prilosec and Nexium Increase Rates of Cardiac Events
in Straightfromthedoc, on December 12, 2007
...s of AstraZeneca - Prilosec and Nexium - are members of a class of drugs known as proton pump inhibitors (PPIs) and are indicated for the treatment of severe gastroesophageal reflux disease ...
New FDA-Approved Label of ED Drugs Contains Risk of Hearing Loss
in Straightfromthedoc, on October 24, 2007
... for the drug Revatio (also a member of this drug class known as phosphodiesterase type 5 (PDE5) inhibitors ) even though Revatio is used to treat pulmonary arterial hypertension (PAH) - a serious ...
Overeating Sugar Could Cause Wrinkles
in Well Woman Blog, on October 21, 2007
...nt your diet with at least 1 mg of vitamins B1 and B6 a day. These vitamins proved to be potent AGE inhibitors in a number of published studies, says David J. Goldberg, MD, a New York City-based derma...
Merck's ISENTRESS™ (raltegravir) Tablets, FDA-Approved for HIV
in Straightfromthedoc, on October 15, 2007
...™ is the first medicine to be approved in a new class of antiretroviral drugs called integrase inhibitors that works by inhibiting the insertion of HIV DNA into human DNA by the integrase enzyme.
A...
Inhibitex Licenses HIV Integrase Inhibitors
in The Biotech Weblog, on October 15, 2007
...
Georgia biotechnology company Inhibitex has licensed a series of HIV integrase inhibitors discovered by Vasu Nair, Georgia Research Alliance Eminent scholar in Drug Discovery at the Uni...
Novel D-Peptides More Potent Against HIV
in The Biotech Weblog, on October 11, 2007
...Our 'D-peptides' offer several potential therapeutic advantages over existing peptide entry inhibitors, which are costly, require high dose injections, and suffer from the emergence of drug-re...
Protein Plaques and Type 2 Diabetes
in Daily Diabetic, on September 13, 2007
... the amount of amyloid formed.
Such findings not only will lead to the development of better IAPP inhibitors in type-2 diabetes but also hold promise for the better understanding and development of ...
FTY720 May Treat Imatinib (Gleevec)- Resistant Leukemia
in The Biotech Weblog, on August 28, 2007
...ia and some cases of acute lymphocytic leukemia. These are fatal leukemias against which Abl kinase inhibitors such as imatinib (Gleevec) fail to induce a long-term response. FTY720 activates protein ...
Aliskiren-Valsartan Combo, Better at Lowering Blood Pressure
in Straightfromthedoc, on July 25, 2007
...ood pressure in patients with hypertension (high blood pressure).
Aliskiren and Valsartan are both inhibitors of the renin system of the kidneys.
[Renin is a vasoconstricting substance (one which c...
Portmanteau Inhibitors: New Anti-HIV Method from U of M
in The Biotech Weblog, on July 24, 2007
...in Toxicity because many drugs are taken at one time.
The new concept is named Portmanteau Inhibitors by the researchers.
Study results were published in a July 4 issue of the Journal of Me...
ED Pills Don't Solve All Erectile Problems
in Straightfromthedoc, on July 12, 2007
... The oral medications known as PDE5 inhibitors - like Viagra® and the likes - may restore a man's sexual function but don't necessarily restore a man's sexual health.
According to D...
Fibrinogen: Blood-Clotting Protein, Inhibits Spinal Cord Regeneration
in The Biotech Weblog, on July 10, 2007
...growth factor receptor. When the second receptor is activated, it inhibits the axonal growth. Other inhibitors have been identified that use the same epidermal growth factor receptor, but this is the ...
Antidepressants and Pregnancy
in Well Woman Blog, on June 30, 2007
...f birth defects is virtually non-existent, except in the case of a few selective serotonin-reuptake inhibitors (SSRIs).
The story goes on, however, to warn that Zoloft and Paxil could cause some prob...
SSRIs May Cause Increased Bone Loss
in Straightfromthedoc, on June 29, 2007
... Speaking of bone health: certain antidepressant drugs - selective serotonin reuptake inhibitors (SSRIs) - may cause increased bone loss in older adults.
SSRIs, are used to treat depression by...
HDAC Inhibitors: Cancer Drug, Can Enhance Long-term Memory
in Straightfromthedoc, on June 7, 2007
... Histone deacetylase (HDAC) inhibitors - cancer drugs currently used in clinical trials to attack cancerous tumors - has been found in mice study by UC Irvine scientists to enhance long-term m...
Shark Cartilage Compound is No Lung Cancer Therapy
in Straightfromthedoc, on June 6, 2007
...cancers when AE-941 was given at higher doses - based on the hypotheses that the cartilage contains inhibitors of angiogenesis and the public's belief that the incidence of cancer in this cartilag...
Anti-obesity Drugs Could Endanger Your Health
in Well Woman Blog, on May 21, 2007
...eople with cardiac risk factors and those who use bronchodilators, take decongestants or use M.A.O. inhibitors or S.S.R.I.'s for depression.
Portion control and a good exercise plan are still th...
ACE-Inhibitor Hypertension Drugs May Help Prevent Alzheimer's Disease
in The Biotech Weblog, on May 11, 2007
...ding to a new study, a class of hypertension medication called angiotensin-converting enzyme (ACE) inhibitors may may help protect older adults from declines in memory and other cognitive function t...
Centrally Active ACE Inhibitors May Help Reduce Risk of Cognitive Decline in Older Adults
in Straightfromthedoc, on May 9, 2007
... Some high blood pressure medicine - especially the types of ACE inhibitors that can reach the brain and may help reduce the inflammation that might contribute to Alzheimer's disease (centra...
Naturally Occurring Peptide in Human Blood Can Block HIV
in Straightfromthedoc, on April 24, 2007
...s, making them "highly promising for further clinical development.
Existing antiretroviral inhibitors being used for HIV treatment can become HIV resistant over time, not to mention the sever...
Heartburn Medication and Your Bones
in Well Woman Blog, on April 21, 2007
...ux Disease ) and your doctor may prescribe an acid reducing group of medications called Proton Pump Inhibitors (PPI). WegGERD.com has this to say about PPIs:
PPI class of drugs, i.e. Prilosec, Nexi...
Energy Booster Creatine May Boost Dying Cells in Parkinson's Disease
in Straightfromthedoc, on April 1, 2007
...#39;s why the current gold standard for therapy is a synthetic dopamine called levodopa and MAO-B inhibitors that prevents the breakdown of dopamine - gearing towards treatment of the condition.
Ac...
DPP-4 Inhibitor JANUVIA® Approved In EU for Type 2 Diabetes
in Daily Diabetic, on March 27, 2007
...in, blood sugar cannot be broken down).
Now, a new class of drugs known as dipeptidyl peptidase-4 inhibitors or DPP-4 inhibitors is capable of enhancing the body's own ability to lower bloo...
NSAIDs (except Aspirin) Increase Risk of Heart Attack and Stroke
in Straightfromthedoc, on March 6, 2007
...d Women's Hospital:
"We believe that some physicians have been prescribing the new COX-2 inhibitors as the first line of treatment. We are turning that around and saying that, for chronic p...
Erectile Dysfunction Drugs May be Better than Nitroglycerin in Protecting Heart
in Straightfromthedoc, on March 5, 2007
...rdiology at VCU, have studied a class of erectile dysfunction drugs known as phosphodiesterase-5 inhibitors as part of ongoing research into heart protection. Both sildenafil and vardenafil have bee...
Pycnogenol® 190 Times More Potently than Prescription Diabetes Medications
in The Biotech Weblog, on February 13, 2007
...lays the uptake of glucose from a meal 190 times more than synthetic prescription alpha-glucosidase inhibitors such as Precose®, and is thus more potent in preventing the typical high glucose peak in...
PPAR-gamma Inhibitors: Potential Anti-Cancer Compounds
in The Biotech Weblog, on February 5, 2007
...e identified a group of compounds called peroxisome proliferator-activated receptor-gamma (PPARγ) inhibitors which may help treat colorectal cancer, and potentially cancers of the esophagus, liver a...
Erectile Dysfunction Drugs Deemed Safe For Diabetics
in Daily Diabetic, on January 31, 2007
...ause a variety of other chronic complications, such as heart disease and high blood pressure, PDE-5 inhibitors used in several erectile dysfunction drugs were shown not to cause many adverse reactions...
Erectile Dysfunction Drugs Effective and Safe for Diabetics
in The Biotech Weblog, on January 26, 2007
...gures may continue to increase. In a recent study, the use of such phosphodiesterase type 5 (PDE-5) inhibitors ( a class of drugs which include Viagra and Levitra) have also been shown to be a safe a...
In Silico Screening of Chinese Herbs Using Random Forest
in The Biotech Weblog, on January 25, 2007
...ple decision trees, has been used to screen a database of Chinese herbal constituents for potential inhibitors against several therapeutically important molecular targets.
About 62 percent of the spe...
BH3 Profiling Determines Sensitivity to Experimental Cancer Drug
in The Biotech Weblog, on January 23, 2007
...o cancer cell death.
BH3 profiling thus identify which cancers are likely to respond to such Bcl-2 inhibitors.
In developing the test, the Letai team first isolated mitochondria from cancer c...
New Drugs Being Developed For Type 2 Diabetes
in Daily Diabetic, on January 23, 2007
... of Biological Chemistry, should in time help researchers to identify potential targets for docking inhibitors that will slow down, but not fully eliminate, the body's overproduction of glucose.
...
Blood Pressure Drugs May Worsen Diabetes
in Daily Diabetic, on January 19, 2007
... to the report, angiotensin- receptor blockers (ARBs) and angiotensin-converting-enzyme (ACE) inhibitors are the blood pressure drugs least associated with diabetes. These are followed by calciu...
Little Evidence Found to Support the Usefulness of Genetic Tests in Depression Treatment
in Straightfromthedoc, on January 5, 2007
...e if the current gene-based tests intended to personalize the dose of selective serotonin reuptake inhibitors (SSRIs) improve patient outcomes or aid in treatment decisions for depression.
The rep...
Five NIMH Research Projects to Fully Understand the Antidepressant Drugs' Link to Suicidality
in Straightfromthedoc, on December 30, 2006
...nderstand the association of antidepressant medications, particularly selective serotonin reuptake inhibitors (SSRIs) , with suicidality (suicidal thoughts and actions) will be funded by The Nationa...
Newest Treatment For Type 2 Diabetes Unleashed
in Daily Diabetic, on December 30, 2006
...ction of sugar by the liver. By enhancing the effect of active incretin hormones in the body, DPP-4 inhibitors improve timely insulin release and ultimately decrease high blood sugar levels in patient...
The American Diabetes Association and American Heart Association Join Forces
in Daily Diabetic, on December 29, 2006
... addition, the statement calls for increased medical interventions, such as the use of statins, ACE inhibitors, and other drugs to manage lipids, blood pressure, and blood glucose levels in people wit...
SaaS in the Asian Context by Springboard Research
in The CIO Weblog, on November 30, 2006
...ng SaaS is the perception that it is more expensive than licensed software. The next most important inhibitors are a lack of SaaS understanding and security concerns.
Among SMEs that had not adopted...
Epoxide Hydrolase Inhibitors from Insects: Potential Drug Candidate Against Heart Arrhythmia
in The Biotech Weblog, on November 27, 2006
...d entomology professor Bruce Hammock led a 16-member team that identified epoxide hydrolase inhibitors as novel and powerful chemical compounds that block an immune system protein known to pl...
India as a market for IT / ITES
in The CIO Weblog, on November 9, 2006
... to work together with customers, government and other stakeholders to remove some of the perceived inhibitors and help develop a conducive environment for healthy, long-term growth of the domestic in...
Engineered Heparans: New Treatments for Alzheimer's disease, under Development
in Straightfromthedoc, on November 1, 2006
...e are currently no drug treatments which target this enzyme because it has proved difficult to find inhibitors using traditional drug discovery approaches. The new compounds, based on the body's n...
ACE Inhibitors May Help Reduce Diabetes Symptoms
in Daily Diabetic, on October 29, 2006
... Another 'off the label' type of medicine is being prescribed to fight diabetes: ACE inhibitors. Originally used to lower blood pressure, these medications seem to have a positive effect o...
Heparin Derivatives: Drug Candidates Against Alzheimers Disease
in The Biotech Weblog, on October 27, 2006
...e are currently no drug treatments which target this enzyme because it has proved difficult to find inhibitors using traditional drug discovery approaches. The new compounds, based on the body's n...
Why Eating Feels So Good: The Neurobiological Explanation
in Straightfromthedoc, on October 24, 2006
...ntly, infusion of ghrelin into the VTA of rats increased their food intake. Conversely, infusion of inhibitors of the ghrelin receptor into the VTA of rats
decreased the amount they consumed after a ...
DPP-4 Inhibitor by Merck: JANUVIA™, Approved by the USFDA for Type 2 Diabetes
in Straightfromthedoc, on October 20, 2006
... Belonging to a class of class of prescription medications called dipeptidyl peptidase-4 (DPP-4) inhibitors, Merck's JANUVIA™(sitagliptin phosphate ) has recently been approved by the U...
Merck KGaA Licenses Glenmark Pharmaceuticals' DPPIV Inhibitor for Type 2 Diabetes
in The Biotech Weblog, on October 17, 2006
...or GRC 8200 , a treatment for type 2 diabetes, currently under Phase II clinical development. DPPIV inhibitors are a class of drugs that work by inhibiting the activity of the DPP-IV enzyme, thereby s...
Diabetics Cautioned: Protect Your Kidneys
in Daily Diabetic, on July 31, 2006
... hypertension, blood pressure should be less than 130/80 mm Hg. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (AII) receptor blockers are types of medications used to lower blood p...
Clinical Trials Begin For New Diabetes Drug
in Daily Diabetic, on July 31, 2006
...ieve the medicine is an innovation in diabetes treatment .
The mechanism of action of DPP-4 inhibitors is distinct from that of any currently available class of glucose lowering agents.
Sitag...
Rho Kinase Inhibitors May Treat Certain Gastrointestinal Disorders
in The Biotech Weblog, on July 19, 2006
An enzyme called Rho kinase has been shown to play a role in maintaining the tone of the internal anal sphincter (IAS). When the IAS tone is too high, the anal sphincter can be hypertensive, and may lead to disorders such as constipation, hemorrhoids, anal fissures , Hirschsprung'...
Allergen Delivery Inhibitors
in Allergies, on July 17, 2006
...loped at the University of Manchester .
The drugs we are developing -- called Allergen Delivery Inhibitors (ADIs) - are designed to disable these allergens so they can no longer eat through the p...
IBM CFO Study 2005
in The CIO Weblog, on June 22, 2006
...hly effective Finance organizations in our study have enabled delivery of insight by addressing its inhibitors: structural complexity and fragmented information. These organizations are:
- Mitigating...
Calcium Antagonists and ACE Inhibitors: Blood Pressure-lowering Drug Combo That Also Reduced Diabetes Risk in Hispanics
in Straightfromthedoc, on June 1, 2006
...rategy that includes medications - specifically calcium antagonists and angiotensin-converting (ACE inhibitors), for example: trandolapril and verapamil. With this medication, not only is blood pressu...
FDA Gives Tentative Approval to New Generic AIDS Drug
in The Biotech Weblog, on May 22, 2006
...HIV medication. Abacavir belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NRTIs) , and is used in combination with other antiretroviral agents to inhibit HIV repl...
Diabetes and HIV: Is There A Connection?
in Daily Diabetic, on May 8, 2006
... blood. While diabetes is a known side-effect of antiretroviral therapy, particularly with protease inhibitors, some studies have claimed a link between the onset of diabetes and HIV infection itself....
Amgen Gains Worldwide Rights to Biovitrum's Lead Candidate For Type 2 Diabetes
in The Biotech Weblog, on February 14, 2006
...the European Union, Australia and New Zealand.
Biovitrum's lead compound, 11beta-HSD1 enzyme inhibitors , are currently under early clinical development.
...
2006 Will Be a Horrible Year for Software Vendors - CEO Right Now
in The CIO Weblog, on January 26, 2006
...ncreased customer satisfaction, and also brought back accountability.
Old Gaurd also have major inhibitors to truly embracing this model. First, they have to build for multi-tenancy (only Siebel o...
Anti-reflux medications and C Difficile
in Straightfromthedoc, on December 20, 2005
...among patients registered in British medical practices.
They found that current use of proton pump inhibitors was linked with nearly three times the rate of CDAD, and the use of H2-receptor antagonis...





